PIPELINE DRUGS
DRUGS IN CLINICAL TRIALS
Directory - Encyclopedia  

Drugs at the Clinical Stage -- In the Pipeline

NEW

Pipeline Drugs for Alzheimer's:

Drugs for Alzheimer's Disease



Pipeline Drugs for Schizophrenia:

Drugs for Schizophrenia


Pipeline Drugs for Drug Abuse and Pain

New Approaches to Drug Addiction Treatment

The Biotech-100 Index includes 100 small cap biotechnology stocks whose product drug pipeline contain at least one drug in either phase II and/or Phase III clinical development. There is a 90% chance of rejection in early-stage phase I clinical trials; a 50% chance in phase II; 20% in phase III; and 10% post-phase III. Companies that are in phase II and III tend to show great promise but still have a high degree of volatiliy.

Pipeline Drugs Company Symbol
Application
ABX-EGF (panitumumab) Abgenix ABGX targets the epidermal growth factor receptor (EGFr), which is over-expressed in a variety of cancers including lung cancer, breast cancer, bladder, pancreatic, colorectal cancer, kidney and head and neck cancer.
ABX-MA1 Abgenix ABGX ABX-MA1 targets a protein called MUC18, a cell-surface adhesion molecule that is highly expressed on metastatic melanoma cells but not on normal skin cells
ACP-103 Acadia ACAD Parkinson's Disease, adjunctive therapy for schizophrenia (Hallucinations, Psychoses)
Onconase (ranpirnase) AlfaCell ACEL Ribonuclease anti-cancer drug,
       
Entereg (alvimopan) Adolor ADLR pain management of POI and OBD
lidocaine patch Adolor ADLR postoperative incisional pain
perifosine Æterna Zentaris Inc AEZS Multiple myeloma and advanced metastatic colorectal cancer -- multiple cancers
SolorelTM (AEZS-130) Æterna Zentaris Inc AEZS Growth hormone secretagogue-- potential applications for the treatment of cachexia
AEZS-108 Æterna Zentaris Inc AEZS Ovarian cancer, endometrial cancer
AG-858 Antigenics Inc. AGEN Chronic myelogenous leukemia (CML)
Oncophage Antigenics Inc. AGEN Metastatic melanoma, Kidney cancer (renal cell carcinoma)
AG-702 Antigenics Inc. AGEN Genital herpes
V -Protectants® (AGI-1067) Atherogenics AGIX chronic inflammatory diseases, such as atherosclerosis, rheumatoid arthritis and asthma
Vivitrex Alkermes ALKS Alchol Dependence
Medisorb Alkermes ALKS Diabetes
AIR Insulin Alkermes ALKS Diabetes
AIR hGH Alkermes ALKS GHD
AIR Epinephrine Alkermes ALKS Anaphylaxis
Pexelizumab Alexion ALXN Cardiopulmonary Bypass, Acute Myocardial Infarction
Eculizumab Alexion ALXN Nephritis, Dermatomyositis , Paroxysmal Nocturnal Hemoglinuria
Efaproxiral Allos Therapeutics ALTH Brain metastases from breast cancer, non-small cell lung cancer, cervical cancer
PDX (pralatrexate) Allos Therapeutics ALTH non-small cell lung cancer, Mesothelioma, non-Hodgkin's Lymphoma
SYMLIN® (pramlintide acetate) Amylin AMLN synthetic version of human amylin -glucose control with type 1 diabetes
exenatide (synthetic exendin-4) Amylin AMLN type 2 diabetes
Isatoribine (ANA245) Anadys ANDS Hepatitis C
ANA 380 Anadys ANDS Hepatitis B
Oral Prodrug ANA971 Anadys ANDS reduce the risk of HCV relapse
AMD3100 AnorMED AOM.TO stem cell mobilizer
AMD070 AnorMED AOM.TO chemokine inhibitor for HIV
Insegia(G17DT immunogen) Aphton Corp APHT cancer and gastrointestinal disease
AP23573 Ariad ARIA solid tumor and blood malignancies
TP10 Avant AVAN Cardiac Surgery
CETi-I Avant AVAN Cholesterol Management
CholeraGarde Avant AVAN Cholera
Ty800 Avant AVAN Typhoid Fever
Injectable Anthrax Avant AVAN Anthrax
Therapore Avant AVAN HIV
Resten-NG Avi Biopharma AVII cardiovascular restenosis
Avicine Avi Biopharma AVII vaccine -- anti-hCG immune response targeting hCG-producing cancer cells
NeuGene compounds Avi Biopharma AVII anti-sense drugs for cancer, polycystic kidney disease, and viral diseases
Neurodex Avanir AVN pseudobulbar affect, neuropathic pain
Avanir Avanir AVN Asthma
AV201 Avigin AVGN severe Parkinson's disease
Phenserine Axonyx AXYX Alzheimer's disease
Theratope Vaccine Biomira BIOM colorectal, metastatic breast cancer
BLP25 Liposome Vaccine Biomira BIOM Prostate, non-small cell lung cancer
Modrenal Bioenvision BIVN Prostate Cancer
Clofarabine (CLOLAR) Bioenvision BIVN pediatric acute lymphoblastic leukemia, solid Tumors
Velostan Bioenvision BIVN post-menopausal advanced breast cancer, bladder cancer
virostat Bioenvision BIVN hepatitis C
GVAX (vaccine) Cell Genesys CEGE Prostate, lung, pancreatic, leukemia, myeloma
CG7870 Oncolytic Virus Therapy Cell Genesys CEGE Prostate cancer
Daptomycin (cubicin) Cubist CBST soft tissue infection, infective endocarditis
HepeX-B Cubist CBST prevention of infection by hepatitis B in liver transplant
Oracea Collagenex Pharmaceuticals Inc CGPI rosacea
E2F Decoy Corgentech CGTK Coronary Bypass Graft, Arterio-Venous Graft
mifepristone ( Corlux) Corcept CORT Psychotic major depression, Alzheimers
Ventavis CoTherix Inc CTRX pulmonary arterial hypertension
Ranexa CV Therapeutics Inc CVTX Chronic Angina
Regadenoson CV Therapeutics Inc CVTX Myocardial Perfusion Imaging
Tecadenoson CV Therapeutics Inc CVTX (PSVT Atrial Fibrillation)
Adentri CV Therapeutics Inc CVTX congestive heart failure (CHF)
Milnacipran Cypress Biosciences CYPB fibromyalgia syndrome (FMS) and related chronic pain conditions
SB-715992 Cytokinetics CYTK multiple forms of cancer, including combination therapy
provenge Dendreon DNDN prostate cancer vaccine
APC8024(Neuvenge) Dendreon DNDN HER-2/neu positive cancers, including breast, ovarian and colorectal cancers
indiplon DOV Pharmaceuticals DOVP insomnia
bicifadine DOV Pharmaceuticals DOVP pain
ocinaplon DOV Pharmaceuticals DOVP generalized anxiety disorder
DOV 216,303 DOV Pharmaceuticals DOVP depression, anxiety and substance abuse
DOV Diltiazen DOV Pharmaceuticals DOVP Angina and Hypertension
DX-88 Dyax DYAX hereditary angioedema (HAE)
DX-890 Dyax DYAX cystic fibrosis (CF),chronic obstructive airways diseases
Thelin (sitaxsentan) Encysive Pharmaceuticals ENCY pulmonary arterial hypertension (PAH)
BIMOSIAMOSE Encysive Pharmaceuticals ENCY inhaled therapy for asthma, psoriasis and atopic dermatitis
TBC3711 Encysive Pharmaceuticals ENCY endothelin A antagonis
Panzem (2-methoxyestradiol) EntreMed ENMD cancer
XL119 Exelixis EXEL bile duct tumors
Macugen(pegaptanib sodium injection) Eyetech Pharmaceuticals EYET wet form of age-related macular degeneration (AMD)
FM-VP4 Forbes Medi-Tech FMTI cholesterol-lowering and anti-atherosclerotic
Genasense® (oblimersen sodium Genta GNTA melanoma, lung and prostate cancers
Ganite® (gallium nitrate injection). Genta GNTA cancer related hypercalcemia
TNFerade GenVec GNVC Tumor necrosis factor alpha gene
TVAX Telomerase Cancer Vaccine (TVAX) Geron GERN prostate cancer
Aquavan Injection Guilford Pharmaceuticals GLFD mild to moderate sedation for non-invasive procedures
GPI 1485 Guilford Pharmaceuticals GLFD Impotence, Prostate Cancer
GPI 5693 Guilford Pharmaceuticals GLFD neuropathic pain
MyVax Genitope Corp GTOP idotypic vaccine for cancer follicular non-Hodgkin's lymphoma (f-NHL).
ACAPODEME GTX Inc. GTXI Prevention of prostate cancer in men with high grade PIN
Andarine GTX Inc. GTXI Cachexia from various types of cancer
Ostarine GTX Inc. GTXI andropause
HE2100 NEUMUNE Hollis-Eden Pharmaceuticals HEPH protecting the body's bone marrow from acute radiation syndrom
PHOSPHONOL Hollis-Eden Pharmaceuticals HEPH protect against DNA mutations (mutagenesis)-- from radiation
(HE2000) IMMUNITIN Hollis-Eden Pharmaceuticals HEPH Malaria and HIV and preclinical benefit in a number of tuberculosis model
       
LymphoStat-B Human Genome Sciences HGSI drugs discovered through genomics-based research
Albuferon Human Genome Sciences HGSI hepatitis C, b?? and a broad range of cancers
HGS-ETRI Human Genome Sciences HGSI apoptosis, in cancer cells.
HGS-TR2J Human Genome Sciences HGSI apoptosis, in cancer cells.
480848 Human Genome Sciences HGSI inhibits atherosclerotic plaques
IC485 ICOS ICOS Chronic Obstructive Pulmonary Disease
Tadalafil ICOS ICOS Benign Prostatic Hyperplasia
FluINsure ID Biomedical Corp IDBE vaccine prevention of influenza (flu)
StreptAvax ID Biomedical Corp IDBE vaccine for prevention of diseases caused by group A streptococcus in children
PPV ID Biomedical Corp IDBE vaccine for the prevention of disease caused by Streptococcus pneumoniae (pneumococcus)
Pagocione Indevus Pharmaceuticals IDEV Stuttering
PRO2000 Indevus Pharmaceuticals IDEV HIV and STD Prevention
IP 751 Indevus Pharmaceuticals IDEV Pain and Inflammation
Aminocandin Indevus Pharmaceuticals IDEV Serious Fungal Infections
HuN901-DM1 Immunogen IMGN cancers that express the CanAg antigen
MLN2704 Immunogen IMGN -targets the prostate-specific membrane antigen (PSMA)
Cantuzumab mertansine Immunogen IMGN cancers that express the CanAg antigen
Reverset Incyte Corp INCY HIV
CCR2 Antagonists Incyte Corp INCY Rheumatoid Arthritis, MS, Neuropathic Pain, Atherosclerosis
Sheddase Inhibitors Incyte Corp INCY Cancer
ADVEXIN Introgen Therapeutics INGN Cancer ?? Advexin (adenoviral p53) --bladder cancer--gene therapy -PI
INGN 241 Introgen Therapeutics INGN tumor suppressor product candidate
INGN 225 Introgen Therapeutics INGN tumor vaccine
Visicol InKline Pharamceuticals INKP Constipation
INKP-102 InKline Pharamceuticals INKP Colon cleansing prior to colonoscopy
IB-Stat InKline Pharamceuticals INKP Symptoms associated with Irritable Bowel Syndrome (IBS)
CEA-Scan Immunomedics IMMU targets tumors that have carcinoembryonic antigen (CEA) on their cell membrane
antisense drugs ISIS Pharmaceuticals ISIS ulcerative colitis, diabetes, MS, cardiovascular disease, cancer, psoriasis
diquafosol tetrasodium (INS365 Ophthalmic) Inspire Pharamceuticals ISPH for the treatment of dry eye disease
INS37217-- Respiratory (denufosol tetrasodium) Inspire Pharamceuticals ISPH cystic fibrosis, retinal disease
IN50589 Inspire Pharamceuticals ISPH Antiplatelet for Platelet Inhibition
Sulodexide (KRX-101) Keryx Biopharmaceuticals KERX diabetic nephropathy
Perifosine (KRX-0401) Keryx Biopharmaceuticals KERX multiple forms of cancer
KS 01-019 Kos Pharmaceuticals KOSP dyslipidemia
KS 01-018 Kos Pharmaceuticals KOSP Periperhal Arterial Disease
Azmacort Kos Pharmaceuticals KOSP treatment of asthma as prophylactic therapy
Targretin Ligand Pharmaceuticals LGND non-small cell lung cancer
ONTAK Ligand Pharmaceuticals LGND B- and T-cell non-Hodgkin's lymphomas and chronic lymphocytic leukemia,
Targretin gel Ligand Pharmaceuticals LGND hand dermatitis
LJP 394 La Jolla Pharmaceuticals LJPC Lupus Erythematosus, Systemic Lupus Nephritis
Riquent® (abetimus sodium La Jolla Pharmaceuticals LJPC systemic lupus erythematosus (SLE)
Ceplene Maxim Pharmaceuticals MAXM Advanced Melanoma, Acute Myeloid Leukemia, Renal Cell Carcinoma, Hepatitis C
Medarex Antibodies Medarex MEDX cancer, inflammation, autoimmune and infectious diseases
Anidulafungin Vicuron Pharmaceuticals MICU anti-fungal
Dalbavancin Vicuron Pharmaceuticals MICU glycopeptide class of antibiotics (hospital infections)
Oxazolidinones Vicuron Pharmaceuticals MICU most-difficult-to-treat, multi-drug-resistant bacteria
Deformylase Inhibitors Vicuron Pharmaceuticals MICU antibiotic -- respiratory tract infections
INTEGRILIN® (EPTIFIBATIDE) Millenium Pharmaceuticals MLNM cardiovascular
VELCADE® (bortezomib)- Millenium Pharmaceuticals MLNM lung, breast, prostate cancers
MLN1202,MLN2704 Millenium Pharmaceuticals MLNM Rheumatoid arthritis, multiple sclerosis, inflammation
Technosphere Insulin System MannKind Corp MNKD pulmonary delivery system for diabetes
Enoximone Myogen MYOG Advanced Chronic Heart Failure
Ambristentan Myogen MYOG Pulmonary Arterial Hypertension
Darusentan Myogen MYOG Uncontrolled Hypertension
Flurizan Myriad Genetics Inc MYGN Alzheimer's, cancer
StaphVAX Nabi Biopharmaceuticals NABI Vaccine for staphylococcus infections
NicVax Nabi Biopharmaceuticals NABI Vaccine for smoking cessation vaccine
Civacir Nabi Biopharmaceuticals NABI Hepatitis C antibody-based therapies
IL13-PE38QQR NeoPharm Inc NEOL Glioblastoma Multiforme brain tumor
Liposomal SN38 NeoPharm Inc NEOL Advanced cancers; including colorectal and lung
Liposomal c-raf Antisense Oligonucleotide NeoPharm Inc NEOL Advanced cancers; including pancreatic (monotherapy and combination with radiation/chemotherapy)
Liposomal Paclitaxel-Easy-to-use NeoPharm Inc NEOL Advanced cancers; including breast cancer, lung and ovarian
Indiplon Neurocrine Biosciences NBIX insomnia via inhibitory neurotransmitter --- GABA
CRF Receptor Antagonis Neurocrine Biosciences NBIX Anxiety and depression
NBL- 5788 Neurocrine Biosciences NBIX Multiple Sclerosis
Urocortin 2 Neurocrine Biosciences NBIX Acute congestive heart failure (CHF)
GnRH antagonists Neurocrine Biosciences NBIX Endometriosis
PREOS® (recombinant human parathyroid hormone) NPS Pharmaceuticals NPSP treatment of osteoporosis
Teduglutide NPS Pharmaceuticals NPSP gastrointestinal disorders including Short Bowel Syndrome
Preotact NPS Pharmaceuticals NPSP Osteoperosis
Calcilytics NPS Pharmaceuticals NPSP Osteoperosis
GlyT-1 NPS Pharmaceuticals NPSP Schizophrenia
Fibrillex Neurochem Inc. NRMX AA Amyloidosis
Alzhemed Neurochem Inc. NRMX Alzheimer's Disease --inhibit the Amyloid Cascade
Cerebril Neurochem Inc. NRMX Hemorrhagic stroke due to cerebral amyloid angiopathy
Memantine (Namenda) Neurobiological Tech NTII progressive neurological impairment due to neuronal injur
XERECEPT -- natural human peptide CRF Neurobiological Tech NTII inhibitor of swelling, or edema
VIPRINEX™ (ancrod) Neurobiological Tech NTII stroke patients -- anticoagulation
BiDil NitroMed NTMD Heart failure, or end-stage cardiovascular disease
Alfimeprase Nuvelo NUVO thrombolytic agent or blood clot dissolver
rNAPc2 Nuvelo NUVO Factor VIIa / Tissue Factor Inhibitor
ARC183 Nuvelo NUVO DNA-based direct thrombin inhibitor-- anticoagulant / anti-thrombotic
BAY 43-9006 Onyx Pharmaceuticals ONXX advanced renal (kidney) cancer
Ramoplanin Oscient Pharmaceuticals OSCI Clostridium difficile-associated diarrhea
FACTIVE Oscient Pharmaceuticals OSCI Intravenous-- Bacterial Infections
CA4P (combretastatin)-- Oxigene OXGN Vascular targeting agent ??CK PHASE
Motexafin gadolinium Pharmacyclics Inc. PCYC anti-cancer product
Motexafin lutetium Pharmacyclics Inc PCYC reduce or eliminate “vulnerable plaque ”
Apan Praecis Pharmaceuticals PRCS Alzheimer's Disease
PPI-2458 Praecis Pharmaceuticals PRCS Non-Hodgkin's Lymphoma/RA
MNTX Progenics Pharmaceuticals PGNX Advanced medical ilness, post-operative ileus, chronic pain
GMX Progenics Pharmaceuticals PGNX Melanoma Cancer
PSMA Progenics Pharmaceuticals PGNX prostate cancer
PRO542 Progenics Pharmaceuticals PGNX HIV
PRO 140 Progenics Pharmaceuticals PGNX HIV
Trexima POZEN Inc. POZN migraine pain
OXYTREX Pain Therapeutics Inc. PTIE severe chronic pain, such as low back, osteoarthritic pain or cancer pain
REMOXY Pain Therapeutics Inc. PTIE proprietary abuse-resistant version of time-release oxycodone
PTI-901 Pain Therapeutics Inc. PTIE chronic Irritable Bowel Syndrome (IBS).
AXOKINE IL-1

Regeneron Pharmaceuticals

REGN potential treatment of obesity
VEGF Trap Regeneron Pharmaceuticals REGN inihibits tumor blood vessel growth
L-4/13 Trap Regeneron Pharmaceuticals REGN treatment in allergy and asthma
IL-1 Trap Regeneron Pharmaceuticals REGN decreases inflammation and blocks cartilage erosion in the joint -- Rhematoid Arthritis
ZADAXIN Sciclone Pharmaceuticals SCLN viral infections-- hepatitis C, and cancer
SCV-07 Sciclone Pharmaceuticals SCLN fight infection
SGN-30 Seattle Genetics SGEN Hodgkin's disease and some types of non-Hodgkin's lymphoma
SGN-15 Seattle Genetics SGEN non-small cell lung cancer
SGN-40 Seattle Genetics SGEN multiple myeloma and non-Hodgkin's lymphoma
XIFAXAN™ (rifaximin) Salix Pharmaceuticals SLXP gastrointestinal- selective, oral antibiotic
ZEGERID Santarus Inc SNTS Heartburn/GERD, Erosive esophagitis, Duodenal ulcers
Orathecin Supergen Inc. SUPG pancreatic cancer
Avicine™ Supergen Inc. SUPG colorectal cancer
Satraplatin Spectrum Pharmaceuticals SPPI Prostate Cancer
SPI-153 Spectrum Pharmaceuticals SPPI Hormone Depenmdent Prostate Cancer
EOquin Spectrum Pharmaceuticals SPPI Bladder Cancer, Radiation Sensitizer
Elsamitrucin Spectrum Pharmaceuticals SPPI

Non-Hodgkin's Lymphoma

prosaptide Savient SVNT peripheral neuropathic pain
puricase Savient SVNT symptomatic gout
fibrimage Savient SVNT diagnostic agent for the detection of deep vein thrombosis
I2S Transkaryotic Therapies TKTX Hunter syndrome
GA-GCB Transkaryotic Therapies TKTX Gaucher disease
TELCYTA (TLK286) Telik Inc. TELK advanced ovarian cancer and non-small cell lung cancer (a selective apoptotic agent)
TELINTRA Telik Inc. TELK myelodysplastic syndrome --Bone marrow stimulant
TNX -355 Tanox Inc. TNOX HIV
T-1249 Trimeris Inc. TRMS HIV
Pivanex Titan Pharmaceuticals TTP Refractory Chronic Lymphocytic Leukemia
DITPA Titan Pharmaceuticals   Congestive Heart Failure
Probuphine Titan Pharmaceuticals   Opiate addition
Spheramine Titan Pharmaceuticals   Advanced Parkinson's
Iloperidone Titan Pharmaceuticals   Schizophrenia
Gallium Maltolate Titan Pharmaceuticals   Bone Disease
OvaRex United Therapeutics Corp UTHR Ovarian Cancer
Remodulin United Therapeutics Corp UTHR Critical limb ischemia (CLI)
UT-231B United Therapeutics Corp UTHR Hepatitis C
Celacade Vasogen Inc. VSGN Chronic Heart Failure, Periperheral Arterial Disease
VP025 Vasogen Inc. VSGN Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis
VX-385 Vertex Pharmaceuticals VRTX HIV infection
Merimepodib Vertex Pharmaceuticals VRTX hepatitis C
VX-950 Vertex Pharmaceuticals VRTX hepatitis C
VX-765 Vertex Pharmaceuticals VRTX cytokine inhibitor of interleukin-1 beta converting enzyme (ICE)
VX-702 Vertex Pharmaceuticals VRTX acute coronary syndromes
Pralnacasan Vertex Pharmaceuticals VRTX inflammatory diseases
VX944, VX630 Vertex Pharmaceuticals VRTX Cancer
DNA Vaccines Vical Inc VICL malaria, cytomegalovirus, eboa, west nile virus, hiv, hepatitis
Avanafil Vivus Inc. VVUS erectile dysfunction
ALISTA Vivus Inc. VVUS female sexual arousal disorder
Testosterone MDTS Vivus Inc. VVUS low sexual desire
Evamist Vivus Inc. VVUS symptoms associated with menopause
Neuprex XOMA LTD XOMA immunologic and inflammatory disorders, cancer and infectious diseases
XMP.629 XOMA LTD XOMA Acne
MLN2222 XOMA LTD XOMA coronary artery bypass graft (CABG) surgery patients.
TransMID Xenova Group XNVA Glioblastoma multiforme (GBM)
XR303 Xenova Group XNVA Pancreatic Cancer
XR5944/XR11576 Xenova Group XNVA Solid Tumors
TA-CD Vaccine Xenova Group XNVA Cocaine addition
TA_NIC Vaccine Xenova Group XNVA Nicotine Addiction
Recombinant human Thrombin Zymogenetics Inc. ZGEN control of bleeding associated with various surgical procedures
-TACI-Ig Zymogenetics Inc. ZGEN autoimmune diseases and for advanced B-cell malignancies
Interleukin 21 (IL-21) Zymogenetics Inc. ZGEN cancer

 
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See also--Pipeline Drugs for Alzheimer's:

Drugs for Alzheimer's Disease

See also:

Pipeline Drugs for Schizophrenia:

Drugs for Schizophrenia

    
     

 


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